Apo-Clozapine

In this factsheet:

• How does Apo-Clozapine work? What will it do for me?
• How should I use Apo-Clozapine?
• What form(s) does Apo-Clozapine come in?
• Who should NOT take Apo-Clozapine?
• What side effects are possible with Apo-Clozapine?
• Are there any other precautions or warnings for Apo-Clozapine?
• What other drugs could interact with Apo-Clozapine?

DIN (Drug Identification Number)

How does Apo-Clozapine work? What will it do for me?

This medication is used to treat schizophrenia when other medications are not effective. Schizophrenia is related to imbalances in certain brain chemicals. This medication helps to rebalance these chemicals.

Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

How should I use Apo-Clozapine?

The recommended dose varies widely based on needs but is usually started at 12.5 mg taken once or twice daily and adjusted gradually upwards according to the doctor's instructions.

It is very important that this medication be taken exactly as prescribed. If you miss a dose of this medication, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. If you miss two or more days of clozapine doses, talk to your doctor before restarting the medication. You may need to start taking the medicine at a lower dose than you were taking previously.

Many things can affect the dose of medication that a person needs, such as the severity of the condition, body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does Apo-Clozapine come in?

25 mg

Each round, light yellow tablet, with score on one side and "C25" on the other side, contains clozapine 25 mg. Nonmedicinal ingredients: anhydrous silica colloidal, lactose monohydrate, magnesium stearate, maize starch, microcrystalline cellulose, povidone, sodium lauryl sulfate and sodium starch glycolate.

100 mg

Each round, light yellow tablet, with score on one side and "C100" on the other side, contains clozapine 100 mg. Nonmedicinal ingredients: anhydrous silica colloidal, lactose monohydrate, magnesium stearate, maize starch, microcrystalline cellulose, povidone, sodium lauryl sulfate and sodium starch glycolate.

Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

Who should NOT take Apo-Clozapine?

This medication should not be used by people who:

• have certain blood disorders (e.g., platelet disorders)
• have active liver disease associated with nausea, loss of appetite, or jaundice (yellowing of skin)
• are in a severely sedated or comatose state
• have severe kidney disease
• have severe heart disease (e.g., myocarditis)
• have uncontrolled epilepsy
• have experienced an allergic reaction to clozapine or any other components of the product

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